Amdocs
Chesterfield, MO
Amdocs makes software for telecom and media providers, including the amAIz generative AI framework and the aOS agentic AI platform.
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St. Louis AI Company Directory
Every St. Louis AI company, organization and program, checked and verified by a real-life human.
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Companies that sell AI software or productsFirms that help you plan, adopt or govern AIFirms that build custom AI for youData companies, data centers and AI computeUniversities, research labs and community meetupsAI training, certificates and workforce programsGovernment, defense and large corporate AI teamsFunders, grants, accelerators and innovation centers
AI products 21AI services 12Infrastructure 6Research and education 12Enterprise and government AI 8Ecosystem 14
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AI products
Sells AI software, hardware or AI-made products.
Assertion AI
St. Louis, MO
Assertion AI uses LLM reasoning to automate how teams build predictive machine learning models, such as churn and fraud models, cutting build time from months to under an hour.
View profileVerifiedBalto
St. Louis, MO
Balto gives contact center agents real-time AI guidance during calls, along with automated quality assurance and voice AI agents.
View profileVerifiedBizzyCar
St. Peters, MO
BizzyCar's AI platform helps auto dealers automate recall outreach, customer retention and service scheduling.
View profileVerifiedCapacity
St. Louis, MO
Capacity offers an AI support automation platform that helps contact centers and help desks answer customers, and is used by more than 20,000 organizations.
View profileVerifiedDigitizer AI
St. Louis, MO
Digitizer AI uses AI to create industrial embroidery machine files in minutes for apparel decoration and embroidery shops.
View profileVerifiedHealthcare Fraud Shield
Chesterfield, MO
Healthcare Fraud Shield sells software that combines proprietary data, AI, rules and algorithms to help health insurers detect fraud, waste and abuse in claims.
View profileVerifiedHire Henry
St. Louis, MO
Hire Henry builds autonomous commercial lawn mowers that use AI and computer vision to mow for commercial landscaping crews.
View profileVerifiedIntramotev
St. Louis, MO
Intramotev builds autonomous battery-electric railcars, called TugVolt, at its St. Louis facility to move freight for rail, industrial and mining customers.
View profileVerifiedLumeris
St. Louis, MO
Lumeris is a value-based care company whose AI care-team member, Tom, schedules screenings, monitors medication adherence and handles patient outreach.
View profileVerifiedMilliporeSigma
St. Louis, MO · Local office
MilliporeSigma, the life science business of Merck KGaA, makes AI software for drug discovery and chemistry, including AIDDISON and SYNTHIA.
View profileVerifiedNEER
St. Louis, MO
NEER uses machine learning to predict where water, sewer and stormwater pipes are likely to fail, helping utilities rank which pipes to replace first.
View profileVerifiedNerdy (Varsity Tutors)
St. Louis, MO
Nerdy, the company behind Varsity Tutors, runs live online learning on its Live+AI platform, with AI tools for tutors, teachers and schools.
View profileVerifiedNeuroFore
St. Louis, MO
NeuroFore is developing technology that flags possible early signs of Parkinson's disease from non-motor symptoms.
View profileVerifiedOpsCompanion
St. Louis, MO
OpsCompanion gives companies software to monitor how employees use AI tools and to control which company data those tools can reach.
View profileVerifiedPrezerv Technologies
St. Louis, MO
Prezerv Technologies uses AI to automatically build 3D maps of underground utilities, so utility, construction and excavation crews know what is below ground before they dig.
View profileVerifiedQuercus Biosolutions
St. Louis, MO
Quercus Biosolutions uses AI design tools from drug discovery to create mini-protein herbicides and other crop protection products.
View profileVerifiedThe Intelligence Factory
St. Louis, MO
St. Louis company building analytical AI for business decisions; its Derive API runs repeatable, checkable analysis and its Envision product gives enterprises a 3D view of their business systems and code.
View profileVerifiedVantor (formerly Maxar Intelligence)
St. Louis, MO · Local office
Vantor, formerly Maxar Intelligence, is a geospatial intelligence firm whose AI-powered platform includes Sentry change detection and Raptor navigation for places without GPS.
View profileVerifiedVigilanceIQ
St. Louis, MO
VigilanceIQ builds AI-enabled tools that assess fatigue risk for fleet drivers and operators before their shifts start.
View profileVerifiedWarrCloud
St. Louis, MO
WarrCloud uses machine learning trained on millions of analyzed warranty claims to speed up automotive warranty processing for dealers.
View profileVerifiedAI services
People-delivered AI work, such as strategy, implementation, data, governance, training and integration.
CEdge
St. Louis, MO
St. Louis IT services firm offering data, AI and machine learning services, including AI-driven analytics and data governance, and labeled AI training datasets built through its Simpack-Edge joint venture for a national security AI program.
View profileVerifiedDigital Radium
St. Louis, MO
St. Louis technology consultancy with an AI consulting practice that helps growing Midwest companies apply AI to catalog enrichment, workflow automation and forecasting, alongside its business software implementation work.
View profileVerifiedEnabled Intelligence
St. Louis, MO · Local office
Enabled Intelligence provides AI and machine learning data labeling for national security agencies, with a largely neurodivergent workforce.
View profileVerifiedGemini Consulting & Services
Chesterfield, MO
Chesterfield-headquartered IT consultancy that implements AI and machine learning on platforms including Azure AI, Amazon SageMaker, SAP Business AI and Salesforce Einstein, and offers generative AI consulting for enterprise applications.
View profileVerifiedOakwood Systems Group
St. Louis, MO
Microsoft-focused technology consultancy that builds AI applications on Azure OpenAI and Microsoft AI Foundry, deploys Microsoft Copilot, and offers machine learning, AI governance and data readiness assessments for AI.
View profileVerifiedObject Computing
St. Louis, MO
Software engineering and technology consulting firm that designs production AI systems, agentic workflows and custom integrations, and helps client engineering teams adopt AI tools and AI-augmented development practices.
View profileVerifiedPerficient
St. Louis, MO
Global consulting and technology services firm headquartered in St. Louis that repositioned in 2026 as an AI-native partner, delivering AI strategy, design, engineering and organizational change for enterprise clients.
View profileVerifiedRubinBrown
St. Louis, MO
Accounting and consulting firm whose AI and data practice offers readiness assessments, AI strategy, implementation, executive education and AI governance for manufacturers, contractors, healthcare and financial services firms and private equity portfolio companies.
View profileVerifiedScale AI St. Louis AI Center
St. Louis, MO · Local office
Scale AI's St. Louis AI Center hires and trains Missourians to do geospatial and generative AI data work for the U.S. government.
View profileVerifiedSketch Development Services
Webster Groves, MO
Software and AI consultancy that builds custom AI-powered applications and AI agents around client workflows, offers AI strategy, and helps companies move AI from experiments into production use.
View profileVerifiedThe AI Hat
St. Louis, MO
AI consulting and training firm led by Mike Allton that runs workshops, keynotes and team training on tools such as Claude, Copilot, ChatGPT and Gemini, and helps small and mid-sized businesses find AI opportunities.
View profileVerifiedWorld Wide Technology
St. Louis, MO
World Wide Technology is a technology integrator that helps enterprises build and secure generative AI through its AI Proving Ground lab and ARMOR AI security framework.
View profileVerifiedInfrastructure
Data centers, compute and connectivity.
CRG (Clayco data center arm)
Festus, MO · Local office
CRG, the data center arm of Clayco, is planning a $6 billion data center campus in Festus that was scaled back after local opposition.
View profileVerifiedCrusoe (Warrenton campus)
Warrenton, MO · Local office
Crusoe, an AI data center developer, has permits for a roughly 340-acre campus in Warrenton with two large data halls.
View profileVerifiedNetrality Data Centers
St. Louis, MO · Local office
Netrality Data Centers owns St. Louis's main carrier hotels, the buildings where networks, carriers and cloud providers connect and exchange traffic.
View profileVerifiedTerraWatt
St. Louis, MO · Local office
TerraWatt is developing a 120 MW data center in Midtown St. Louis for AI and cloud workloads and has proposed a 200 MW campus in Alton.
View profileVerifiedTierPoint
St. Louis, MO
TierPoint runs four colocation data centers in the St. Louis area and is building an AI-ready data center downtown for GPU and AI workloads.
View profileVerifiedSpirit of St. Louis AI Innovation Center
St. Louis, MO
The Spirit of St. Louis AI Innovation Center is a planned shared AI compute and innovation hub led by GeoSTL with WWT, AWS, Google and other partners.
View profileVerifiedResearch and education
Universities, labs, and training and placement programs.
Donald Danforth Plant Science Center
Creve Coeur, MO
The Donald Danforth Plant Science Center is a plant science institute that uses drone imagery and AI to study crop traits such as grain quality.
View profileVerifiedLaunchCode
St. Louis, MO
LaunchCode is a nonprofit that trains people and places them in tech careers, with a growing focus on AI-ready skills.
View profileVerifiedLindenwood University AI Programs
St. Charles, MO
St. Charles university offering human-centered AI programs, an AI track in computer science and a Human-Centered AI and Interactive Technology Hub, and seeking state approval in 2026 for a BA in Applied AI.
View profileVerifiedMaryville University AI Programs
St. Louis, MO
Maryville University offers an online master's degree in AI and in-person AI workforce training with LaunchCode.
View profileVerifiedSaint Louis University AI Programs
St. Louis, MO
Saint Louis University offers a Master of Science in Artificial Intelligence, an accelerated computer science to AI path and an Applied AI and Decision Analytics master's degree, listed in its 2026-2027 catalog.
View profileVerifiedSIUE (Southern Illinois University Edwardsville)
Edwardsville, IL
Public university in Edwardsville that, with The Wedge Innovation Center in Alton, runs a Grow with Google AI Learnathon helping students, alumni, residents and employers earn the Google AI Professional Certificate, with optional college credit.
View profileVerifiedSLU Geospatial Center
St. Louis, MO
Saint Louis University's Geospatial Center is a university-wide center for GeoAI, quantum sensing and geospatial analytics research.
View profileVerifiedTaylor Geospatial
St. Louis, MO
Taylor Geospatial is a St. Louis nonprofit that develops and commercializes geospatial AI, with a focus on open science.
View profileVerifiedUMSL Graduate Certificate in AI
St. Louis, MO
UMSL's Graduate Certificate in Artificial Intelligence is a 12-credit program from the university's computer science department.
View profileVerifiedWashU AI Initiative
St. Louis, MO
WashU's AI Initiative is a campus-wide program for AI literacy, curriculum, tools and governance across the university.
View profileVerifiedCenter for Health AI (WashU Medicine and BJC)
St. Louis, MO
The Center for Health AI, run by WashU Medicine and BJC Health System, builds and tests AI for patient care, hospital operations and clinical workflows.
View profileVerifiedNGA GAIA Lab at Moonshot Labs
St. Louis, MO · Local office
NGA's GAIA Lab at Moonshot Labs lets St. Louis-area students do AI geoscience research alongside NGA scientist mentors.
View profileVerifiedEnterprise and government AI
Employers and public agencies with a named local AI program or a visible local AI team.
Air Mobility Command
Scott Air Force Base, IL
Air Force major command at Scott Air Force Base that uses AI to consolidate data for leaders, analyze exercise observations, pull lessons learned from operational messages and support war-gaming for air mobility operations.
View profileVerifiedCentene
St. Louis, MO
St. Louis-based health insurer that uses AI in administrative communications with members and is exploring interactive AI tools to help Medicaid patients and rural community health workers with early steps in care.
View profileVerifiedCenter for Health AI (WashU Medicine and BJC)
St. Louis, MO
The Center for Health AI, run by WashU Medicine and BJC Health System, builds and tests AI for patient care, hospital operations and clinical workflows.
View profileVerifiedEdward Jones (Gen AI program and Ventures)
St. Louis, MO
Edward Jones runs an in-house generative AI skills program built on its Mack tool, and its venture arm invests in fintech startups.
View profileVerifiedEmerson
St. Louis, MO
St. Louis-headquartered automation company whose industrial AI portfolio, including AspenTech tools, Aspen Virtual Advisor and the Project Beyond platform, helps manufacturers design plants, modernize control systems and move toward autonomous operations.
View profileVerifiedMercy
Chesterfield, MO
Chesterfield-based health system running more than 200 AI models, using Aidoc imaging AI to flag findings, Microsoft DAX Copilot for ambient visit notes, and AI tools for nurse handoffs and virtual nursing.
View profileVerifiedNGA GAIA Lab at Moonshot Labs
St. Louis, MO · Local office
NGA's GAIA Lab at Moonshot Labs lets St. Louis-area students do AI geoscience research alongside NGA scientist mentors.
View profileVerifiedU.S. Transportation Command (USTRANSCOM)
Scott Air Force Base, IL
Defense logistics command headquartered at Scott Air Force Base that builds AI tools with MIT Lincoln Laboratory for patient movement and mass casualty response, and in 2026 used AI agents to plan airfield capacity and maintenance.
View profileVerifiedEcosystem
Investors, grants, accelerators, innovation centers and community groups.
AI Tinkerers St. Louis
St. Louis, MO
AI Tinkerers St. Louis is a recurring meetup where local builders give and watch technical AI demos.
View profileVerifiedArch Grants
St. Louis, MO
Arch Grants is a nonprofit that gives grants to St. Louis startups and is the region's largest source of new AI startups.
View profileVerifiedBioGenerator
St. Louis, MO
BioGenerator, part of BioSTL, is a nonprofit early-stage investor in St. Louis bioscience startups, including AI health tools.
View profileVerifiedCultivation Capital
St. Louis, MO
Cultivation Capital is a St. Louis venture capital firm whose portfolio includes AI software companies.
View profileVerifiedGDG St. Louis
St. Louis, MO
Local Google Developer Group chapter of about 480 members that runs hands-on AI sessions for developers, including Build with AI workshops, vibe coding with Google AI Studio and DevFest sessions on building AI agents.
View profileVerifiedGeoSTL
St. Louis, MO
Nonprofit backbone organization, launched in 2026 from the GeoFutures roadmap, that coordinates the St. Louis geospatial and GeoAI economy and administers the Spirit of St. Louis AI Innovation Center and its AI competitions.
View profileVerifiedGlobal AI Saint Louis
St. Louis, MO
Global AI Saint Louis is the local chapter of the Global AI Community, running AI talks, bootcamps and events such as AgentCon.
View profileVerifiedPyData St. Louis
St. Louis, MO
Volunteer NumFOCUS community for people who use open-source data tools, hosting St. Louis meetups on data science, machine learning and AI, including a 2026 session on enterprise modernization with agentic AI.
View profileVerifiedSpirit of St. Louis AI Innovation Center
St. Louis, MO
The Spirit of St. Louis AI Innovation Center is a planned shared AI compute and innovation hub led by GeoSTL with WWT, AWS, Google and other partners.
View profileVerifiedT-REX
St. Louis, MO
T-REX is a downtown innovation center and geospatial hub that houses NGA's Moonshot Labs software factory and accelerator.
View profileVerifiedTechSTL
St. Louis, MO
Regional tech council that runs STL TechWeek and its AI Summit, and offers AI bootcamps for small businesses with the Urban League and AI programming for nonprofits with the Community Foundation and United Way.
View profileVerifiedWashU Skandalaris Center and Mayfield AI Garage
St. Louis, MO
The AI Garage pairs WashU's Skandalaris Center and McKelvey School of Engineering with venture firm Mayfield to help students and faculty start AI companies.
View profileVerifiedEdward Jones (Gen AI program and Ventures)
St. Louis, MO
Edward Jones runs an in-house generative AI skills program built on its Mack tool, and its venture arm invests in fintech startups.
View profileVerifiedTaylor Geospatial
St. Louis, MO
Taylor Geospatial is a St. Louis nonprofit that develops and commercializes geospatial AI, with a focus on open science.
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