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St. Louis AI Company Directory

Every St. Louis AI company, organization and program, checked and verified by a real-life human.

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Companies that sell AI software or productsFirms that help you plan, adopt or govern AIFirms that build custom AI for youData companies, data centers and AI computeUniversities, research labs and community meetupsAI training, certificates and workforce programsGovernment, defense and large corporate AI teamsFunders, grants, accelerators and innovation centers
14 resultsEcosystem

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Arch Grants

St. Louis, MO

Arch Grants is a nonprofit that gives grants to St. Louis startups and is the region's largest source of new AI startups.

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BioGenerator

St. Louis, MO

BioGenerator, part of BioSTL, is a nonprofit early-stage investor in St. Louis bioscience startups, including AI health tools.

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GeoSTL

St. Louis, MO

Nonprofit backbone organization, launched in 2026 from the GeoFutures roadmap, that coordinates the St. Louis geospatial and GeoAI economy and administers the Spirit of St. Louis AI Innovation Center and its AI competitions.

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PyData St. Louis

St. Louis, MO

Volunteer NumFOCUS community for people who use open-source data tools, hosting St. Louis meetups on data science, machine learning and AI, including a 2026 session on enterprise modernization with agentic AI.

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TechSTL

St. Louis, MO

Regional tech council that runs STL TechWeek and its AI Summit, and offers AI bootcamps for small businesses with the Urban League and AI programming for nonprofits with the Community Foundation and United Way.

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